Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus
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- 作者：J.J. David Ho1 ; 2 ; Miling Wang1 ; 2 ; Timothy E. Audas1 ; 2 ; Deukwoo Kwon2 ; 3 ; Steven K. Carlsson4 ; Sara Timpano5 ; Sonia L. Evagelou5 ; Shaun Brothers4 ; 6 ; Mark L. Gonzalgo2 ; 7 ; Jonathan R. Krieger8 ; Steven Chen2 ; 3 ; 9 ; James Uniacke5 ; 11 ; Stephen Lee1 ; 2 ; 10 ; 11 ; stephenlee@med.miami.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：oxygen ; hypoxia ; cancer ; translation ; RNA sequencing ; SILAC ; eIF4E ; eIF4E2 ; eIF4F ; HIF
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：14
- 期：6
- 页码：1293-1300
- 全文大小：2550 K
文摘
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O2 stimulus reprograms protein output by altering mRNA translation efficiency
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eIF4FH mediates hypoxic cap-dependent protein synthesis
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eIF4F and eIF4FH triage mRNAs to generate O2-responsive translatomes
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Hypoxia-inducible proteins are controlled by translation efficiency, not mRNA levels