Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage
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- 作者：Timothy M. Chlon1 ; Sonya Ruiz-Torres1 ; Logan Maag1 ; Christopher N. Mayhew2 ; Kathryn A. Wikenheiser-Brokamp3 ; 4 ; Stella M. Davies1 ; Parinda Mehta1 ; Kasiani C. Myers1 ; James M. Wells2 ; Susanne I. Wells1 ; susanne.wells@cchmc.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：6
- 期：1
- 页码：44-54
- 全文大小：3406 K
文摘
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Self-renewal but not pluripotency of iPSCs depends on FA pathway function
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Hyperactive CHK1 limits self-renewal in a conditional FA-deficient iPSC model
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CHK1 inhibition rescues long-term growth of FA-deficient iPSCs