BAFF overexpression increases lymphocytic infiltration in Sjögren's target tissue, but only inefficiently promotes ectopic B-cell differentiation
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- 作者：Jian Ding1 ; Wei Zhang1 ; Scott Haskett ; Alex Pellerin ; Shanqin Xu ; Britta Petersen ; Luke Jandreski ; Stefan Hamann ; Taylor L. Reynolds ; Timothy S. Zheng ; Michael Mingueneau ; michael.mingueneau@biogen.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BAFF ; Autoimmunity ; B cells ; Ectopic germinal center ; Sjö ; gren's syndrome
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：169
- 期：Complete
- 页码：69-79
- 全文大小：1938 K
文摘
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The NOD model of Sjögren's does not show spontaneous ectopic B cell differentiation.
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Hydrodynamic delivery of BAFF in NOD increases functionally-active BAFF levels.
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BAFF overexpression enhances MHC class II expression in glandular B cells.
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BAFF overexpression enhances lymphocytic infiltration in glandular tissue.
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BAFF overexpression increases the number of GC glandular B cells, but inefficiently.