Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient
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- 作者：Jon Hazeldinea ; Janet M. Lorda ; Peter Hampsona ; b ; P.Hampson@bham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ageing ; Innate immunity ; Immunesenescence ; Infection ; Trauma
- 刊名：Ageing Research Reviews
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：24
- 期：part_PB
- 页码：349-357
- 全文大小：712 K
文摘
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160">Aging is associated with a dysregulated immune and inflammatory response.
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Older adults have worse outcome post-trauma, including increased infection rates.
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Impaired immunity and delayed resolution of inflammation may underlie poor outcome.
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A detailed understanding of the mechanism(s) responsible has yet to be determined.