Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
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- 作者：Magdalena Przybylaa ; 1 ; Claire H. Stevensa ; 1 ; Julia van der Hovena ; Anne Harastaa ; Mian Bia ; Arne Ittnera ; Annika van Hummela ; John R. Hodgesb ; Olivier Piguetb ; c ; Tim Karlb ; d ; Michael Kassioue ; Gary D. Housleyf ; Yazi D. Keg ; Lars M. Ittnera ; b ; h ; 2 ; l.ittner@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author ; Janet van Eersela ; 2
- 关键词：Frontotemporal dementia ; Tau ; Transgenic mouse model ; Behavior
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：19 September 2016
- 年：2016
- 卷：631
- 期：Complete
- 页码：24-29
- 全文大小：1361 K
文摘
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The amygdala is a major site of progressive tau pathology in P301S mutant tau-expressing TAU58/2 mice.
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TAU58/2 mice present with early-onset disinhibition-like behavior.
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Aged TAU58/2 mice are hyperactive in the open field arena.