SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes
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- 作者：Dorota Rogacka ; drogacka@imdik.pan.pl" class="auth_mail" title="E-mail the corresponding author ; Agnieszka Piwkowska ; Irena Audzeyenka ; Stefan Angielski ; Maciej Jankowski
- 关键词：Podocyte ; Hyperglycemia ; Insulin resistance ; SIRT1 ; AMPK ; Resveratrol
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：349
- 期：2
- 页码：328-338
- 全文大小：1828 K
文摘
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SIRT1 protein level and activity decrease in insulin resistant podocytes.
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SIRT1 downregulation inhibits AMPK, but not Akt activity in podocytes.
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SIRT1 downregulation abolishes the effect of insulin on glucose uptake.
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Insulin-dependent increase of AMPK activity was suppressed in SIRT1-depleted cells.
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Treatments activating SIRT1 and AMPK may improve insulin resistance of podocytes.