Is the polycystic ovary syndrome associated with chronic inflammation per se?

详细信息    查看全文

• 作者：Magdalena Olszanecka-Glinianowicz ; Michał ; Banaś ; Barbara Zahorska-Markiewicz ; Joanna Janowska ; Piotr Koceł ; ak ; Paweł ; Madej ; Katarzyna Klimek
• 关键词：Proinflammatory cytokines ; Obesity ; Polycystic ovary syndrome
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：133
• 期：2
• 页码：197-202
• 全文大小：141 K

文摘

The aim of the present study was to evaluate serum concentrations of tumor necrosis factor-α (TNF-α), TNF-soluble receptors, and IL-6 in obese women without additional diseases and obese women with polycystic ovary syndrome (PCOS).

Study design

The study group consisted of 39 obese women with PCOS and 34 age-matched obese women without additional disease were included as controls. Blood glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured by the enzymatic procedure. Plasma insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), androstenedione, total and free testosterone, cortisol, progesterone, 17OH-progesterone, estradiol, and sex hormone binding globulin (SHBG) were measured by a commercial radioimmunoassay (RIA). Tumor necrosis factor-alpha (TNF-α), soluble TNF receptors (sTNFRs), and IL-6 were determined by an ELISA.

Results

We did not observe any differences in serum concentrations of TNF-α between obese women with and without PCOS. Serum concentrations of sTNFR1 and sTNFR2 were significantly higher in PCOS patients compared with controls; however, serum concentrations of IL-6 were significantly lower in PCOS patients.

Conclusions

Our findings suggest that PCOS is not associated with chronic inflammation.