Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
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- 作者：Biola M. Javierre1 ; 11 ; Oliver S. Burren2 ; 11 ; Steven P. Wilder3 ; 11 ; Roman Kreuzhuber3 ; 4 ; 5 ; 11 ; Steven M. Hill6 ; 11 ; Sven Sewitz1 ; Jonathan Cairns1 ; Steven W. Wingett1 ; Csilla Vá ; rnai1 ; Michiel J. Thiecke1 ; Frances Burden4 ; 5 ; Samantha Farrow4 ; 5 ; Antony J. Cutler2 ; Karola Rehnströ ; m4 ; 5 ; Kate Downes4 ; 5 ; Luigi Grassi4 ; 5 ; Myrto Kostadima3 ; 4 ; 5 ; Paula Freire-Pritchett1 ; Fan Wang6 ; The BLUEPRINT Consortium Joost H. Martens ; Bowon Kim ; Nilofar Sharifi ; Eva M. Janssen-Megens ; Marie-Laure Yaspo ; Matthias Linser ; Alexander Kovacsovics ; Laura Clarke ; David Richardson ; Avik Datta ; Paul Flicek
- 关键词：gene regulation ; chromosome conformation ; promoter capture Hi-C ; non-coding genetic variation ; disease gene prioritization
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1369-1384.e19
- 全文大小：17401 K
文摘
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High-resolution maps of promoter interactions in 17 human primary blood cell types
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Interaction patterns are cell type specific and segregate with the hematopoietic tree
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Promoter-interacting regions enriched for regulatory chromatin features and eQTLs
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Promoter interactions link non-coding GWAS variants with putative target genes