Association of 3′ nearby gene BTLA polymorphisms with the risk of renal cell carcinoma in the Polish population
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- 作者：Anna Partyka ; M.Sc.a ; Krzysztof Tupikowski ; M.D. ; Ph.D.b ; Anna Kolodziej ; M.D. ; Ph.D.b ; Romuald Zdrojowy ; M.D. ; Ph.D.b ; Agnieszka Halon ; M.D. ; Ph.D.c ; Bartosz Malkiewicz ; M.D. ; Ph.D.b ; Janusz Dembowski ; M.D. ; Ph.D.b ; Irena Frydecka ; M.D. ; Ph.D.a ; Lidia Karabon ; Ph.D.a ; b ; lkarabon@iitd.pan.wroc.pl" class="auth_mail" title="E-mail the corresponding author ; lkarabon@wp.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：BTLA ; Coinhibitory molecule ; Gene polymorphisms ; Renal cancer
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：34
- 期：9
- 页码：419.e13-419.e19
- 全文大小：219 K
文摘
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The frequency of rs1982809G allele carriers (genotype GG+AG) is significantly higher in patients with RCC as compared to the controls.
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In patients with clear-cell RCC with high-grade tumors, the frequency of rs1982809[GG] genotype is significantly higher as compared to those with low-grade tumors or to the controls.
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Haplotype of rs2705511C/rs1982809G/rs9288952A/rs9288953T/rs2705535C/rs1844089G increased the risk of RCC by 46%.