Identification and characterization of a novel NOD-like receptor family CARD domain containing 3 gene in response to extracellular ATP stimulation and its role in regulating LPS-induced innate immune response in Japanese flounder (Paralichthys olivaceus)
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- 作者：Shuo Lia ; 1 ; shuo76@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoli Chena ; Gaixiang Haoa ; Xuyun Gengb ; Wenbin Zhanc ; Jinsheng Suna ; jssun1965@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：NLR ; NLRC3 ; Extracellular ATP ; Lipopolysaccharide-induced innate immunity ; Paralichthys olivaceus
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：79-90
- 全文大小：5187 K
文摘
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A novel NLRC3 gene (poNLRC3) was identified from Japanese flounder Paralichthys olivaceus.
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poNLRC3 is dominantly expressed in the Japanese flounder head kidney macrophages.
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poNLRC3 expression was significantly modulated by extracellular ATP stimulation and immune challenges.
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poNLRC3 positively regulates the LPS and ATP-induced innate immune response in the Japanese flounder HKM cells.