ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster

详细信息    查看全文

• 作者：Jarrod J. Mousa<sup>asup> ; Rachel C. Newsome<sup>asup> ; Ye Yang<sup>bsup> ; Christian Jobin<sup>bsup> ; Steven D. Bruner<sup>asup><sup> ; sup><sup>bruner@ufl.edusup>
• 关键词：Multidrug transporter ; Natural product ; Microbiome ; Drug biosynthesis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1233-1239
• 全文大小：1717 K
• 卷排序：482

文摘

ClbM is a cation promiscuous MATE multidrug transporter. The role of key residues were identified in both the cation and proton binding. The biologically relevant substrate for ClbM is the natural product precolibactin.