- 作者：Catherine Krasnik ; Victor M. Montori ; Gordon H. Guyatt ; Diane Heels-Ansdell ; Jason W. Busse
- 关键词：Premenstrual syndrome ; Premenstrual dysphoric disorder ; Bright light therapy ; Meta-analysis
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2005
- 出版时间：September 2005
- 年：2005
- 卷：193
- 期：3
- 页码：658-661
- 全文大小：193 K
Objective
This systematic review summarizes the evidence from randomized clinical trials of bright light therapy for treatment of premenstrual dysphoric disorder.Study design
The authors performed a systematic review and meta-analysis of randomized clinical trials. They searched MEDLINE, AMED, CINAHL, Digital Dissertations, EMBASE, and the Cochrane Central Register of Controlled Trials. The main outcome measure was the change in depressive symptom scores as measured by the Hamilton Depression Rating Scale and the Beck Depression Inventory.
Results
Four crossover trials studying a total of 55 participants met inclusion criteria. Three trials showed similar results; one fully unblinded trial showed a much larger effect. The pooled effect size from the random-effects model of the 3 higher quality trials was −0.20 (95 % CI −0.48 to 0.07).
Conclusion
The small size of trials and correspondingly wide confidence limits, and methodologic limitations of the trials, leaves the impact of bright light therapy for relief of premenstrual depressive symptoms uncertain. The current evidence justifies neither enthusiastic dissemination nor confident rejection of this therapeutic modality.