17^th Century Variola Virus Reveals the Recent History of Smallpox

详细信息    查看全文

• 作者：Ana T. Duggan¹ ; ¹⁹ ; ^{duggana@mcmaster.ca} ; Maria F. Perdomo² ; ¹⁹ ; Dario Piombino-Mascali³ ; ¹⁹ ; Stephanie Marciniak¹ ; Debi Poinar¹ ; Matthew V. Emery¹ ; Jan P. Buchmann⁴ ; Sebastian Duchê ; ne⁴ ; ⁵ ; Rimantas Jankauskas³ ; Margaret Humphreys⁶ ; G. Brian Golding⁷ ; John Southon⁸ ; Alison Devault⁹ ; Jean-Marie Rouillard⁹ ; ¹⁰ ; Jason W. Sahl¹¹ ; Olivier Dutour¹² ; ¹³ ; Klaus Hedman² ; ¹⁴ ; Antti Sajantila¹⁵ ; Geoffrey L. Smith¹⁶ ; Edward C. Holmes⁴ ; ^{edward.holmes@sydney.edu.au} ; Hendrik N. Poinar¹ ; ⁷ ; ¹⁷ ; ¹⁸ ; ²⁰ ; ^{poinarh@mcmaster.ca}
• 关键词：variola virus ; smallpox ; ancient DNA ; Lithuanian Mummy Project ; evolution ; molecular clock ; phylogeny
• 刊名：Current Biology
• 出版年：2016
• 出版时间：19 December 2016
• 年：2016
• 卷：26
• 期：24
• 页码：3407-3412
• 全文大小：2704 K
• 卷排序：26

文摘

Variola virus genome was reconstructed from a 17th century mummified child The archival strain is basal to all 20th century strains, with same gene degradation Molecular-clock analyses show that much of variola virus evolution occurred recently