Control of multiple arthropod vector infestations with subolesin/akirin vaccines

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• 作者：Juan A. Moreno-Cid^a ; Jos&#233 ; M. P&#233 ; rez de la Lastra^a ; Margarita Villar^a ; Maribel Jim&#233 ; nez^b ; Rocí ; o Pinal^c ; Agustí ; n Estrada-Peñ ; a^d ; Ricardo Molina^b ; Javier Lucientes^c ; Christian Gortá ; zar^a ; Jos&#233 ; de la Fuente^a ; ^e ; ^{josedejesus.fuente@uclm.es} ; ^{jose_delafuente@yahoo.com} ; the SUB/AKR Vaccine Study Group ¹
• 关键词：Akirin ; Arthropod ; Mosquito ; Sand fly ; Subolesin ; Tick ; Vaccine ; Immunology
• 刊名：Vaccine
• 出版年：2013
• 出版时间：6 February, 2013
• 年：2013
• 卷：31
• 期：8
• 页码：1187-1196
• 全文大小：1651 K

文摘

Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54-92 % ), Q41 vaccination had the highest vaccine E in mosquitoes (99 % ) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28 % ) and sand fly (26 % ) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD.