Analysis of titanium and other metals in human jawbones with dental implants - A case series study

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• 作者：Xiuli He^a ; ^b ; Franz-Xaver Reichl^a ; ^b ; Yan Wang^a ; ^b ; Bernhard Michalke^c ; Stefan Milz^d ; Yang Yang^a ; ^b ; Philipp Stolper^e ; Gabriele Lindemaier^f ; Matthias Graw^f ; Reinhard Hickel^b ; Christof Hö ; gg^a ; ^b ; ^{christof.hoegg@lrz.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Titanium content ; Human jawbones ; Dental implants ; Ti particles
• 刊名：Dental Materials
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：32
• 期：8
• 页码：1042-1051
• 全文大小：2571 K

文摘

The aim of this study was to measure titanium (Ti) content in human jawbones and to show that Ti was released from dental implants inserted into these jawbones.

Methods

Seven samples from four human subjects with dental implants were analysed as test group and six bone samples of similar topographical regions from six human subjects without implants served as control. The contents of various elements in human jawbones were detected by inductively coupled plasma optical emission spectrometry. The distributions of various isotopes in human mandibular bone were measured with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Histological analyses of undecalcified, Giemsa-Eosin stained mandible sections were performed by light microscopy and particles were identified in human bone marrow by scanning electron microscope-energy dispersive X-ray analysis.

Results

In test group only Ti content was significantly higher compared to control group. The mean contents of Ti were 1940 μg/kg in test group and 634 μg/kg in control group. The highest Ti content detected in human mandibular bone was 37,700 μg/kg-bone weight. In samples 4–7 (human subjects II–IV), increased Ti intensity was also detected by LA-ICP-MS in human mandibular tissues at a distance of 556–1587 μm from implants, and the intensity increased with decreasing distance from implants. Particles with sizes of 0.5–40 μm were found in human jawbone marrow tissues at distances of 60–700 μm from implants in samples 4–7.

Significance

Ti released from dental implants can be detected in human mandibular bone and bone marrow tissues, and the distribution of Ti in human bone was related to the distance to the implant.