Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines
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- 作者：Bangalore Prabhashankar Arathia ; Poorigali Raghavendra-Rao Sowmyaa ; Gini Chempakathinal Kuriakosec ; Kariyappa Vijaya ; Vallikannan Baskaranb ; Chelliah Jayabaskaranc ; Rangaswamy Lakshminarayanaa ; rlnarn21@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lycopene oxidation products ; Cytotoxicity ; Apoptosis ; Reactive oxygen species ; Free radicals ; UPLC-MS
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：265-276
- 全文大小：2708 K
文摘
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Lycopene doses influences variably in different cancer cell lines.
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Chemically induced lycopene oxidised products (COL) were characterized by MS (APCI)+ mode.
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COL products decreased cell viability with depleted GSH and increased MDA levels in cancer cells.
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COL products induced apoptosis with intermediate ROS generation in MCF-7, PC-3 and HeLa cancer cell lines.