In vivo and in vitro effectiveness of Azadirachta indica-synthesized silver nanocrystals against Plasmodium berghei and Plasmodium falciparum, and their potential against malaria mosquitoes
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- 作者：Kadarkarai Murugan<sup>asup> ; Chellasamy Panneerselvam<sup>bsup> ; Christina Mary Samidoss<sup>asup> ; Pari Madhiyazhagan<sup>asup> ; Udaiyan Suresh<sup>asup> ; Mathath Roni<sup>asup> ; Balamurugan Chandramohan<sup>asup> ; Jayapal Subramaniam<sup>asup> ; Devakumar Dinesh<sup>asup> ; Rajapandian Rajaganesh<sup>asup> ; Manickam Paulpandi<sup>asup> ; Hui Wei<sup>csup> ; Al Thabiani Aziz<sup>bsup> ; Mohamad Saleh Alsalhi<sup>dsup> ; Sandhanasamy Devanesan<sup>dsup> ; Marcello Nicoletti<sup>esup> ; Roman Pavela<sup>fsup> ; Angelo Canale<sup>gsup> ; Giovanni Benelli<sup>gsup><sup> ; sup><sup>g.benelli@sssup.it" class="auth_mail" title="E-mail the corresponding authorsup><sup> ; sup><sup>benelli.giovanni@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Arbovirus ; Anopheles stephensi ; Botanical byproducts ; Culicidae ; Filariasis ; Nanobiotechnology
- 刊名：Research in Veterinary Science
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：106
- 期：Complete
- 页码：14-22
- 全文大小：737 K
文摘
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Neem-synthesized Ag nanoparticles were studied by UV–vis, SEM, EDX, XRD and FTIR.
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AgNP were mostly spherical in shape, crystalline in nature, with a size range of 35–60 nm.
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AgNP acted as larvicides and pupicides against the malaria vector Anopheles stephensi.
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In vitro, AgNP were toxic to chloroquine-resistant Plasmodium falciparum parasites.
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In vivo, AgNP effectively inhibited the growth of Plasmodium berghei in albino mice.