Sunitinib loaded chitosan nanoparticles formulation and its evaluation

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• 作者：Jayapal John Joseph<sup>asup><sup> ; sup><sup>1sup><sup> ; sup><sup>tgjosephsargunam@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; D. Sangeetha<sup>asup><sup> ; sup><sup>dsangeetha@vit.ac.in" class="auth_mail" title="E-mail the corresponding authorsup> ; Thandapani Gomathi<sup>bsup><sup> ; sup><sup>2sup><sup> ; sup><sup>chemist.goms@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup>
• 关键词：Sunitinib ; Chitosan nanoparticles ; Ionic crosslinking
• 刊名：International Journal of Biological Macromolecules
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：952-958
• 全文大小：1862 K

文摘

The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of <200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery.