Bone regeneration using injectable BMP-7 loaded chitosan microparticles in rat femoral defect
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文摘

Chitosan microparticles preparation eliminates the use of toxic chemicals.

Microparticles are biomechanically stable and did not degrade within 12 weeks.

High bone surface and connectivity density suggests good connectivity in new bone.

Increased bundled collagen suggests biomechanically superior new bone formation.

Nanogram level of BMP-7 is not sufficient for significant bone formation in vivo.

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