伪-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway
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- 作者：Wen-Tsan Wenga ; 1 ; bppig@yahoo.com.tw" class="auth_mail ; Shih-Chung Huangb ; e ; 1 ; Sghung@hotmail.com" class="auth_mail ; Yi-Ling Mac ; e ; ylma@vghks.gov.tw" class="auth_mail ; Hoi-Hung Chand ; hoihungchan@gmail.com" class="auth_mail ; Shih-Wei Linf ; Shiwey@yahoo.com.tw" class="auth_mail ; Jian-Ching Wuf ; djbluestyle338@hotmail.com" class="auth_mail ; Chang-Yi Wuc ; cywu@mail.nsysu.edu.tw" class="auth_mail ; Zhi-Hong Weng ; wzh@mail.nsysu.edu.tw" class="auth_mail ; E-Ming Wange ; emwang@vghks.gov.tw" class="auth_mail ; Chao-Liang Wua ; h ; 2 ; wumolbio@mail.ncku.edu.tw" class="auth_mail ; Ming-Hong Taie ; f ; i ; 2 ; minghongtai@gmail.com" class="auth_mail
- 关键词：伪-MSH ; 伪-melanocyte-stimulating hormone ; MC-Rs ; melanocortin receptors ; HUVECs ; human umbilical vein endothelial cells ; VEGF ; vascular endothelial growth factor ; VEGFR2 ; VEGF receptor 2
- 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
- 出版年：June 2014
- 年：2014
- 卷：1840
- 期：6
- 页码：1850-1860
- 全文大小：1925 K
文摘
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伪-MSH inhibits angiogenesis in vivo and in vitro at physiological concentrations.
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伪-MSH is a potent angiogenesis inhibitor targeting at endothelial VEGF/VEGFR2 signaling.
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MC-1R and MC-2R participated in 伪-MSH-mediated angiogenesis inhibition.