The epidemiology of Lp-PLA₂: Distribution and correlation with cardiovascular risk factors in a population-based cohort

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• 作者：Margaretha Persson ; Jan-Å ; ke Nilsson ; Jeanenne J. Nelson ; Bo Hedblad ; Gö ; ran Berglund
• 关键词：Cardiovascular disease ; Epidemiology ; Lp-PLA₂ ; Risk factor
• 刊名：Atherosclerosis
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：190
• 期：2
• 页码：388-396
• 全文大小：160 K

文摘

Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA₂ appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA₂ in a large population-based cohort and to determine associations between Lp-PLA₂ and other risk factors for CVD. The study group consisted of participants from the Malmö Diet and Cancer study (1992–1994). Lp-PLA₂ (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA₂ activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA₂ activity and LDL (r = 0.45) and LDL/HDL ratio (r = 0.54) and a strong inverse correlation to HDL (r = −0.31). The correlations between Lp-PLA₂ mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA₂ activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA₂ is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19 % and 35 % of the variation in Lp-PLA₂ mass and activity respectively.