Determinant of left atrial dilation in patients with hypertrophic cardiomyopathy: A real-time 3-dimensional echocardiographic study

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• 作者：Fabrice Bauer ; MD^a ; Takahiro Shiota ; MD ; FACC^a ; ^{Shiotat@ccf.org} ; Richard D. White ; MD^a ; Harry M. Lever ; MD^a ; Jian Xin Qin ; MD^a ; Jeannie Drinko ; RDCS^a ; Maureen Martin ; RDCS^a ; Hiroyuki Tsujino ; MS^a ; Marta Sitges ; MD^a ; Yong Jin Kim ; MD^a ; James D. Thomas ; MD^a
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2004
• 出版时间：September 2004
• 年：2004
• 卷：17
• 期：9
• 页码：968-975
• 全文大小：315 K

文摘

To identify the determinants of left atrial (LA) dilation for patients with hypertrophic obstructive cardiomyopathy (HOCM), first we validated LA volume determination by real-time 3-dimensional echocardiography using magnetic resonance imaging in patients. Subsequently, real-time 3-dimensional echocardiography and 2-dimensional Doppler echocardiography were performed in 60 patients with HOCM and in 17 age-matched control subjects. LA volumes and left ventricular (LV) filling pressures were higher for patients with HOCM than in control subjects. By stepwise multilinear regression analysis, LV end-diastolic pressure, resting LV outflow tract pressure gradient, and LV wall thickness were significant determinants of LA dilation. However, ¦Ó, ?dP/dt, LV stiffness, provokable pressure gradient, and mitral regurgitation did not have any independent relationship with LA volumes. Therefore, it is concluded that LA volume can be accurately determined by real-time 3-dimensional echocardiography; and LA dilation in patients with HOCM is related to LV filling pressure, LV outflow tract pressure gradient, and LV wall thickness.