Studies of mixed liposomes with novel sorbyl functionalized head group lipids

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• 作者：Saliya N. Ratnayaka ; ^{saliya@arizona.edu} ; El Hadj Elandaloussi¹ ; Bryan D. Korth ; Robert B. Bates ; Jeffrey Pyun ; Henry K. Hall ; S. Scott Saavedra
• 关键词：Sorbyl groups ; Polymerizable lipids ; Langmuir isotherms ; Mixed liposomes
• 刊名：Chemistry and Physics of Lipids
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：165
• 期：8
• 页码：809-817
• 全文大小：517 K

文摘

Three novel polymerizable amphiphiles with a sorbyl-substituted head group were synthesized and systematically characterized. These amphiphiles are neutral in charge. None of these molecules forms vesicles by itself, presumably due to lack of amphiphilicity and/or extensive head group interaction. Therefore, mixed vesicles were formed with other fluid lipids such as DPenPC, eggPC, or DOPC. We investigated the properties of these mixtures in both vesicles and Langmuir films. The Langmuir isotherms show formation of monolayers by all three molecules. However, the isotherms for mixed monolayers suggest that two components are largely immiscible to the mixing lipid. Under polymerization conditions, mixed vesicles of these amphiphiles form oligomers, suggesting that in spite of a larger head group, they form mesophases.