The Midterm Outcomes of Bioprosthetic Pulmonary Valve Replacement in Children
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- 作者：Takeshi Shinkawa ; MD⁎ ; TShinkawa@uams.edu" class="auth_mail" title="E-mail the corresponding author ; newriverjp@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author ; Chiajung K. Lu ; MD⁎ ; Carl Chipman ; RN⁎ ; Xinyu Tang ; PhD&dagger ; ; Jeffrey M. Gossett ; MS&dagger ; ; Michiaki Imamura ; MD ; PhD⁎
- 关键词：congenital heart disease ; CHD ; pulmonary valve ; pediatric
- 刊名：Seminars in Thoracic and Cardiovascular Surgery
- 出版年：2015
- 出版时间：Autumn 2015
- 年：2015
- 卷：27
- 期：3
- 页码：310-318
- 全文大小：1142 K
文摘
The purpose of this study was to assess the outcomes of bioprosthetic pulmonary valve replacement (PVR) in children. This is a retrospective review of all bioprosthetic PVR in children (≤20-year old) between 1992 and 2013 at a single institution. Most outcomes studied included pulmonary valve reintervention and bioprosthetic valve function. A total of 136 bioprosthetic PVRs were identified for 123 patients. The median age and body weight at the time of operation were 13.2 years and 48.4 kg. There were 1 early death and 3 late deaths during the median follow-up of 7.2 years (0-22.0 years). The actuarial transplant-free survival was 97.6% at 10 years. There were 43 bioprosthesis reinterventions with 29 reoperations and 14 catheter-based interventions. The freedom from bioprosthesis reintervention was 89.6% and 55.0% at 5 and 10 years, respectively. Echocardiographic bioprosthesis dysfunction (≥moderate bioprosthesis insufficiency, ≥50 mm Hg peak gradient through bioprosthesis, or bioprosthesis endocarditis with vegetation) was found in 57 bioprostheses. The freedom from bioprosthesis dysfunction was 74.0% and 32.8% at 5 and 10 years, respectively. Results from the Cox proportional hazards models showed that age had significant association with freedom from bioprosthesis reintervention and freedom from bioprosthesis dysfunction (P < 0.001 and P = 0.03), whereas bioprosthesis type had nonsignificant association with freedom from bioprosthesis dysfunction (P = 0.068). Bioprosthetic PVR in children had excellent early outcomes but rapidly deteriorating midterm outcomes. Careful and close follow-up are necessary for children with bioprosthesis in the pulmonary position.