Pulsed ultrasound expands the extracellular and perivascular spaces of the brain
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- 作者：David S. Hersha ; b ; Ben A. Nguyenc ; Jimena G. Dancya ; b ; Arjun R. Adapaa ; b ; Jeffrey A. Winklesb ; d ; e ; Graeme F. Woodwortha ; b ; Anthony J. Kima ; b ; f ; g ; akim@smail.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Victor Frenkelb ; c ; VFrenkel@som.umaryland.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：aCSF ; artificial cerebrospinal fluid ; BBB ; blood-brain barrier ; CSF ; cerebrospinal fluid ; CNS ; central nervous system ; D* ; effective diffusion coefficient ; dECS ; diameter of the extracellular space ; ECS ; extracellular space ; GLS ; glial-lymphatic system ; ISATP ; spatial average temporal peak intensity ; MPT ; multiple particle tracking ; PBS ; phosphate-buffered saline ; PVS ; perivascular space ; PDI ; polydispersity index ; PEG ; polyethylene glycol ; PS ; polystyrene ; PVS ; perivascular space ; TEM ; transmis
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：543-550
- 全文大小：2917 K
文摘
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Pulsed ultrasound can enlarge the pore size of the brain extracellular space.
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These ultrastructural changes are not associated with widespread tissue disruption.
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The effects of ultrasound on the extracellular space are heterogeneous.
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These effects may preferentially affect perivascular regions.