Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer
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- 作者：Jeffrey M. Bhasin1 ; 2 ; Byron H. Lee3 ; Lars Matkin2 ; Margaret G. Taylor2 ; Bo Hu4 ; Yaomin Xu5 ; Cristina Magi-Galluzzi6 ; Eric A. Klein3 ; Angela H. Ting1 ; 2 ; tinga@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：13
- 期：10
- 页码：2135-2146
- 全文大小：3409 K
文摘
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Pervasive, focal hypermethylation distinguishes low- from high-grade prostate cancer
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High-grade-specific changes are most commonly outside promoters and CpG islands
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Intergenic regions are enriched for functional elements including EZH2 binding sites
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High-grade versus cancer-specific changes have different potential functions