MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis
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- 作者：Francisca F. Vasconcelos1 ; Alessandro Sessa2 ; Cá ; tia Laranjeira1 ; Alexandre A.S.F. Raposo1 ; Vera Teixeira1 ; Daniel W. Hagey3 ; Diogo M. Tomaz1 ; Jonas Muhr3 ; Vania Broccoli2 ; Diogo S. Castro1 ; 4 ; dscastro@igc.gulbenkian.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：MyT1 ; Ascl1 ; neurogenesis ; Notch signaling ; Hes1 ; transcription ; Rbpj
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：469-483
- 全文大小：5065 K
文摘
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MyT1 promotes neurogenesis downstream Ascl1
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MyT1 represses Notch1 receptor and many of its downstream target genes
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MyT1 represses Hes1 expression by direct DNA binding and competition with RBPJ
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Ascl1 suppresses Notch signaling cell-autonomously while promoting differentiation