Effects of serostatus and gender on the HRV-16-induced local immune response
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- 作者：Rebecca M. Kocha ; rebecca.koch@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Matthijs Koxa ; Peter Pickkersa ; Marien I. de Jongeb ; on behalf of the Radboudumc Immunoforce groupRebecca M. Kocha ; Matthijs Koxa ; Corné ; van den Kieboomb ; Gerben Ferwerdab ; Jelle Gerretsena ; Sandra ten Bruggencatec ; Johannes G. van der Hoevena ; Marien I. de Jongea ; Peter Pickkersa
- 关键词：GMP ; good medical practice ; HRV ; human rhinovirus ; RSV ; respiratory syncytial virus ; S- ; seronegative ; S+ ; seropositive ; TCID50 ; tissue infective dose in 50% of subjects
- 刊名：Vaccine
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：34
- 期：35
- 页码：4087-4091
- 全文大小：406 K
文摘
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HRV-seropositivity results in a diminished immune response upon HRV infection.
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Gender does not influence the HRV-induced immune response.
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Only seronegative subjects should be included in future HRV studies.
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Both sexes can be included without stratification in future HRV studies.