The performance of acoustic radiation force impulse imaging in predicting liver fibrosis in chronic liver diseases

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• 作者：Yi-Hung Lin^b ; Ming-Lun Yeh^b ; ^c ; Ching-I Huang^b ; Jeng-Fu Yang^b ; Po-Cheng Liang^a ; ^b ; Chung-Feng Huang^b ; ^c ; Chia-Yen Dai^b ; ^c ; ^d ; Zu-Yau Lin^b ; ^c ; Shinn-Cherng Chen^b ; ^c ; Jee-Fu Huang^b ; ^c ; ^d ; ^{jfliver@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Ming-Lung Yu^b ; ^c ; ^d ; Wan-Long Chuang^b ; ^c ; ^d
• 关键词：Acoustic radiation force impulse imaging ; Chronic liver disease ; Liver fibrosis
• 刊名：The Kaohsiung Journal of Medical Sciences
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：32
• 期：7
• 页码：362-366
• 全文大小：255 K

文摘

Sonography-based noninvasive liver fibrosis assessment is promising in the prediction of treatment efficacy and prognosis in chronic liver disease (CLD) patients. Acoustic radiation force impulse imaging (ARFI) is a newly-developed transient elastography (TE) method integrated into a conventional ultrasound machine. The study aimed to assess the performance of ARFI imaging in the diagnosis of liver fibrosis in Taiwanese CLD patients. We also aimed to search for the optimal cut-off values in different fibrosis stages. A total of 60 CLD patients (40 males; mean age, 51.8 ± 11 years) were consecutively included. They received standard ARFI measurement within 2 weeks at the time of liver biopsy. There were eight patients with Metavir fibrosis stage 0 (F0), 16 patients with F1, 20 patients with F2, eight patients with F3, and eight patients with F4, respectively. The mean values among patient with F0, F1, F2, F3, and F4 were 1.17 ± 0.13, 1.30 ± 0.17, 1.31 ± 0.24, 2.01 ± 0.45, and 2.69 ± 0.91, respectively (p < 0.001). The optimal cut-off ARFI value for significant fibrosis (F ≥ 2) was 1.53 with the accuracy of 0.733, while it was 1.66 for advanced fibrosis (F ≥ 3) with the accuracy of 0.957. Our study demonstrated that ARFI imaging is competent for fibrosis diagnosis, particularly in CLD patients with advanced fibrosis.