Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol
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- 作者：Ali Yasrebia ; Anna Hsieha ; Kyle J. Mamounisa ; b ; Elizabeth A. Krumma ; c ; Jennifer A. Yanga ; c ; Jason Magbya ; Pu Hua ; Troy A. Roepkea ; b ; c ; d ; ta.roepke@rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arcuate nucleus ; Ghrelin ; Neuropeptide y ; Fasting ; Diet-induced obesity ; 17β-Estradiol
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：422
- 期：Complete
- 页码：42-56
- 全文大小：2534 K
文摘
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Fasting in males had differential effects on expression of Foxo1 and Ucp2 expression.
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In males, DIO suppressed ARC and NPY Ghsr and Cpt1c expression.
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In females, E2 augmented ARC Ghsr, Cpt1c, and Foxo1 but suppressed NPY Foxo1.
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In females, DIO suppressed ARC Agrp and augmented NPY Cpt1c.
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Ghrelin suppressed M-current activity by ∼50% in NPY neurons from fed male mice.