Synthesis of tertiary carbinamines

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• 作者：Muthoni G. Kamau ; ^{muthoni.kamau@bms.com} ; Lalgudi S. Harikrishnan ; Heather J. Finlay ; Jennifer X. Qiao ; Ji Jiang ; Michael A. Poss ; Mark E. Salvati ; Ruth R. Wexler ; R. Michael Lawrence
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：25 March, 2012
• 年：2012
• 卷：68
• 期：12
• 页码：2696-2703
• 全文大小：2306 K

文摘

An efficient synthesis of tertiary carbinamines using a one-pot, three-component reaction employing TMSCl activation of an intermediate imine salt followed by addition of an organometallic is described. An optimized second generation chiral synthesis of select tertiary carbinamines utilizing the Ellman sulfinamine was subsequently developed on a multi-gram scale and is also described.