Short- and long-term dopamine depletion causes enhanced beta oscillations in the cortico-basal ganglia loop of parkinsonian rats
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- 作者：Maximilian H. Beck ; Jens K. Haumesser ; Johanna Kü ; hn ; Jennifer Altschü ; ler ; Andrea A. Kü ; hn ; Christoph van Riesen ; christoph.van-riesen@charite.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; 6-OHDA ; Reserpine ; Beta oscillations ; Gamma oscillations ; Cortico-basal ganglia loop
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：286
- 期：Complete
- 页码：124-136
- 全文大小：1635 K
文摘
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Enhanced beta power was found in the basal ganglia of both PD models.
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An increase in cortical beta power can be only found in the chronic 6-OHDA model.
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Beta peak frequencies differ profoundly between the models in the basal ganglia.
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Our data support the theory of a relation between beta oscillations and akinesia.
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Our study questions the motor cortex as a generator of beta oscillations in PD.