AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
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- 作者：Chunmei Chang1 ; Hua Su1 ; Danhong Zhang1 ; Yusha Wang1 ; Qiuhong Shen1 ; Bo Liu1 ; Rui Huang1 ; Tianhua Zhou1 ; Chao Peng3 ; Catherine C.L. Wong3 ; Han-Ming Shen4 ; Jennifer Lippincott-Schwartz5 ; Wei Liu1 ; 2 ; liuwei666@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：60
- 期：6
- 页码：930-940
- 全文大小：3501 K
文摘
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GAPDH is essential for glucose starvation stimulated Sirt1 activation and autophagy
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Phosphorylation at Ser122 by AMPK mediates GAPDH nuclear entry
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GAPDH directly interacts with Sirt1 in the nucleus
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Interaction with GAPDH displaces Sirt1 from DBC1