Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer

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• 作者：Elizabeth  ; P. Murchison¹ ; ^{elizabeth.murchison@sanger.ac.uk} ; Ole  ; B. Schulz-Trieglaff² ; Zemin Ning¹ ; Ludmil  ; B. Alexandrov¹ ; Markus  ; J. Bauer² ; Beiyuan Fu¹ ; Matthew Hims² ; Zhihao Ding¹ ; Sergii Ivakhno² ; Caitlin Stewart¹ ; Bee  ; Ling Ng¹ ; Wendy Wong² ; Bronwen Aken¹ ; Simon White¹ ; Amber Alsop³ ; Jennifer Becq² ; Graham  ; R. Bignell¹ ; R.  ; Keira Cheetham² ; William Cheng¹ ; Thomas  ; R. Connor¹ ; Anthony  ; J. Cox² ; Zhi-Ping Feng⁴ ; ⁵ ; Yong Gu¹ ; Russell  ; J. Grocock² ; Simon  ; R. Harris¹ ; Irina Khrebtukova⁶ ; Zoya Kingsbury² ; Mark Kowarsky⁴ ; Alexandre Kreiss⁷ ; Shujun Luo⁶ ; John Marshall¹ ; David  ; J. McBride¹ ; Lisa Murray² ; Anne-Maree Pearse⁸ ; Keiran Raine¹ ; Isabelle Rasolonjatovo² ; Richard Shaw² ; Philip Tedder² ; Carolyn Tregidgo² ; Albert  ; J. Vilella⁹ ; David  ; C. Wedge¹ ; Gregory  ; M. Woods⁷ ; Niall Gormley² ; Sean Humphray² ; Gary Schroth⁶ ; Geoffrey Smith² ; Kevin Hall² ; Stephen  ; M.J. Searle¹ ; Nigel  ; P. Carter¹ ; Anthony  ; T. Papenfuss⁴ ; ¹⁰ ; P.  ; Andrew Futreal¹ ; Peter  ; J. Campbell¹ ; Fengtang Yang¹ ; David  ; R. Bentley² ; Dirk  ; J. Evers² ; Michael  ; R. Stratton¹ ; ^{mrs@sanger.ac.uk}
• 刊名：Cell
• 出版年：2012
• 出版时间：17 February 2012
• 年：2012
• 卷：148
• 期：4
• 页码：780-791
• 全文大小：1402 K

文摘

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Summary

The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently genetically diverged during its spread across Tasmania. The devil cancer genome contains more than 17,000 somatic base substitution mutations and bears the imprint of a distinct mutational process. Genotyping of somatic mutations in 104 geographically and temporally distributed Tasmanian devil tumors reveals the pattern of evolution and spread of this parasitic clonal lineage, with evidence of a selective sweep in one geographical area and persistence of parallel lineages in other populations.

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