Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke

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• 作者：Alberto Oviedo^b ; ¹ ; Stefan Lebrun^a ; ¹ ; Ulrike Kogel^a ; Jenny Ho^b ; Wei Teck Tan^b ; Bjoern Titz^a ; Patrice Leroy^a ; Gregory Vuillaume^a ; Monali Bera^c ; Florian Martin^a ; Gregory Rodrigo^c ; Marco Esposito^a ; Ruth Dempsey^a ; Nikolai V. Ivanov^a ; Julia Hoeng^a ; Manuel C. Peitsch^a ; Patrick Vanscheeuwijck^a ; ^{Patrick.vanscheeuwijck@pmi.com}
• 关键词：Inhalation ; Potential reduced risk product ; Heat-not-burn ; Pulmonary inflammation ; Toxicity ; Menthol
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：81
• 期：supp_S2
• 页码：S93-S122
• 全文大小：3581 K
• 卷排序：81

文摘

Toxicological assessment of a mentholated heat-not-burn product,THS2.2M. THS2.2M aerosol induces no pulmonary inflammation. THS2.2M causes lower changes in respiratory tract than smoke from reference. Gene and protein expression data showed no new adverse effects of THS2.2M aerosol. Addition of menthol to reference cigarette does not alter the toxicity of smoke.