Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells
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- 作者：Sø ; ren Fisker Schmidt1 ; 6 ; 7 ; Jesper Grud Skat Madsen1 ; 2 ; 6 ; Kari Ø ; sterli Frafjord1 ; Lars la Cour Poulsen1 ; 8 ; Sofia Salö ; 3 ; Michael Boergesen1 ; 9 ; Anne Loft1 ; 7 ; Bjø ; rk Ditlev Larsen1 ; Maria Stahl Madsen1 ; Jens Juul Holst2 ; 4 ; Pierre Maechler5 ; Louise Torp Dalgaard3 ; Susanne Mandrup1 ; 10 ; s.mandrup@bmb.sdu.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：metabolism ; pancreatic β cells ; β cells ; proliferation ; glucose ; ChREBP ; RORγ ; ChIP-seq ; RNA-seq
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：16
- 期：9
- 页码：2359-2372
- 全文大小：4597 K
文摘
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Glucose reprograms the transcriptional network of INS-1E β cells in a biphasic manner
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ChREBP is a central regulator of the first wave of the glucose response
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Induction of cell-cycle genes requires ChREBP-induced transcription factors
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RORγ is required for full glucose-induced proliferation of INS-1E and primary β cells