A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy
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- 作者：Rohith Srivas1 ; 2 ; 9 ; 11 ; John Paul Shen1 ; 3 ; 9 ; 10 ; Chih Cheng Yang4 ; Su Ming Sun5 ; Jianfeng Li6 ; 7 ; Andrew M. Gross8 ; James Jensen8 ; Katherine Licon1 ; 2 ; Ana Bojorquez-Gomez2 ; Kristin Klepper1 ; Justin Huang8 ; Daniel Pekin1 ; Jia L. Xu1 ; Huwate Yeerna1 ; Vignesh Sivaganesh1 ; Leonie Kollenstart5 ; Haico van Attikum5 ; Pedro Aza-Blanc4 ; Robert W. Sobol6 ; 7 ; Trey Ideker1 ; 2 ; 3 ; 9 ; tideker@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：63
- 期：3
- 页码：514-525
- 全文大小：3554 K
文摘
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We find a resource of conserved and divergent interactions for the design of cancer therapy
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A global yeast screen directs network assembly in human cancer cells
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As a rule, co-functionality and context stability predict translation to humans
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There are many interactions involving clinically relevant genes, including BLM and XRCC3