Association of DNA methylation and monoamine oxidase A gene expression in the brains of different dog breeds
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- 作者：JungWoo Eoa ; 1 ; Hee-Eun Leea ; 1 ; Gyu-Hwi Nama ; 1 ; Yun-Jeong Kwona ; Yuri Choia ; Bong-Hwan Choib ; Jae-Won Huhc ; Minkyu Kimd ; Sang-Eun Leee ; Bohyun Seof ; Heui-Soo Kima ; khs307@pusan.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：MAOA ; monoamine oxidase ; TSS ; transcription start site ; VNTR ; variable tandem repeat ; qRT-PCR ; quantitative reverse transcription PCR ; BSP ; Bisulfite Genomic Sequencing PCR ; GS ; German shepherd ; Bp ; base pair
- 刊名：Gene
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：580
- 期：2
- 页码：177-182
- 全文大小：714 K
文摘
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The monoamine oxidase A (MAOA) gene is an important candidate gene.
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MAOA encodes an enzyme regulating the metabolism of key neurotransmitters.
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The patterns of MAOA expression and DNA methylation may be involved in breed-specific or individual behavior.
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The transcription levels of MAOA were also different in the brains of different dog breeds.
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The differential expression and DNA methylation of MAOA may contribute to differences in behavioral phenotypes of breeds.