Determination of manassantin B in rat plasma using a high performance liquid chromatography with fluorescence detection and its quantitative application to pharmacokinetic study
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- 作者：Jae-Young Leea ; 1 ; Jae-Hyoung Songb ; 1 ; In-Soo Yoonc ; Hyun-Jeong Kob ; Dae-Duk Kima ; Hyun-Jong Chob ; hjcho@kangwon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Manassantin B ; Validation ; HPLC ; Fluorescence detection ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：1011
- 期：Complete
- 页码：121-127
- 全文大小：875 K
文摘
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A simple and sensitive analytical method of manassantin B in plasma was developed.
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HPLC with fluorescence detector was adopted for its quantitative analysis.
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Precision and accuracy values in all tests were within the acceptable ranges.
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Developed method was successfully applied to pharmacokinetic study in rats.