Effects of trimethoprim on life history parameters, oxidative stress, and the expression of cytochrome P450 genes in the copepod Tigriopus japonicus
详细信息 查看全文
- 作者：Jeonghoon Han1 ; Min-Chul Lee1 ; Duck-Hyun Kim ; Young Hwan Lee ; Jun Chul Park ; Jae-Seong Lee ; jslee2@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trimethoprim ; Copepod ; Tigriopus japonicus ; Cytochrome P450 ; Oxidative stress ; Reactive oxygen species ; Biomarker
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：159-165
- 全文大小：520 K
文摘
- •
The TMP LC50-48 h in nauplius was 156 mg/L and LC50-96 h in adult was 200 mg/L.
- •
TMP-exposed Tigriopus japonicus showed developmental delay and reproduction impairment.
- •
TMP induced oxidative stress via the regulation of antioxidant related genes.
- •
TMP induced expression of three Tj-CYP genes (Tj-CYP3024A2, Tj-CYP3024A3 and Tj-CYP3027C2).