Information Integration and Energy Expenditure in Gene Regulation
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- 作者：Javier Estrada1 ; Felix Wong1 ; 2 ; Angela DePace1 ; Jeremy Gunawardena1 ; jeremy@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：166
- 期：1
- 页码：234-244
- 全文大小：2171 K
文摘
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Gene regulation is understood quantitatively in terms of a bacterial paradigm
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This paradigm cannot account for the sharpness of gene expression in development
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Information integration or energy expenditure can explain the sharpness
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Hill functions form a “Hopfield barrier” for sharpness at thermodynamic equilibrium