HE4, CA125 and risk of ovarian malignancy algorithm (ROMA) as diagnostic tools for ovarian cancer in patients with a pelvic mass: An Italian multicenter study
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Multicenter prospective study evaluating CA125, HE4 and ROMA in EOC diagnosis.

ROMA presented well balanced diagnostic performance, with higher SN than HE4 and higher SP than CA125.

HE4 seems to be more efficient than CA125 in ruling in EOC patients in the disease group.

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