Nicotine enhancement and reinforcer devaluation: Interaction with opioid receptors

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• 作者：Ari P. Kirshenbaum ; ¹ ; ^{akirshenbaum@smcvt.edu} ; Jesse A. Suhaka¹ ; Jessie L. Phillips ; Maiary Voltolini de Souza Pinto
• 关键词：Enhancement ; Naloxone ; Nicotine ; Opioid ; Reinforcement ; Withdrawal
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：1-7
• 全文大小：619 K
• 卷排序：150

文摘

Sucrose reinforcement in rats was used as a preclinical model for food consumption upon nicotine-dosing discontinuation. Nicotine (0.4 mg/kg) enhanced sucrose reinforcement and devalued sucrose reinforcement upon discontinuation of dosing. Naloxone (0.3 & 3.0 mg/kg) attenuated reinforcement enhancement by nicotine, but did not prevent devaluation by nicotine. The highest dose of naloxone (3.0 mg/kg) in combination with nicotine, interfered with sucrose reinforcement during dosing. Opioid antagonism by itself did not interfere with sucrose reinforcement at the doses used. Discontinuation of the higher (3.0 mg/kg) but not lower (0.3 mg/kg) dose of naloxone, devalued sucrose reinforcement.