Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen

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• 作者：Jessica A. Linderman¹ ; ⁹ ; ¹⁰ ; Mariko Kobayashi⁸ ; ⁹ ; Vinayak Rayannavar¹ ; ⁷ ; John J. Fak⁸ ; Robert B. Darnell⁸ ; Moses V. Chao² ; ³ ; ⁴ ; ⁵ ; ⁷ ; Angus C. Wilson¹ ; ⁶ ; Ian Mohr¹ ; ⁶ ; ¹¹ ; ^{ian.mohr@med.nyu.edu}
• 关键词：interferon ; latency ; reactivation ; herpesvirus ; gene expression ; neurons
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1312-1323
• 全文大小：2478 K
• 卷排序：18

文摘

A neuron-intrinsic response to interferon (IFN) directly blocks HSV-1 reactivation IFN sensitivity is limited to a temporal window at the beginning of reactivation IFNs block phase I, a burst of HSV-1 gene expression confined to reactivating neurons HSV-1 ICP0 produced in phase I selectively blocks IFNγ, but not IFNβ, action