Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific
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- 作者：Lisa H. Tostanoski
- 关键词：lymph node ; immune tolerance ; biomaterial ; autoimmunity ; microparticle ; regulatory T cell ; vaccine ; nanoparticle ; CNS ; multiple sclerosis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2940-2952
- 全文大小：5315 K
文摘
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- <p id="p0010">A single intra-lymph node (i.LN.) particle dose reverses autoimmunity/paralysis in micep>
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- <p id="p0015">Efficacy is dependent on delivery of encapsulated self-antigen to lymph nodes (LNs)p>
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- <p id="p0020">i.LN. delivery of particles reprograms local LN cell composition and functionp>
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- <p id="p0025">Altered local function in LNs promotes systemic but antigen-specific tolerancep>