Defining immunological dysfunction in sepsis: A requisite tool for precision medicine
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- 作者：Jesú ; s F. Bermejo-Martina ; b ; jfbermejo@saludcastillayleon.es" class="auth_mail" title="E-mail the corresponding author ; David Andaluz-Ojedab ; c ; dandaluz@saludcastillayleon.es" class="auth_mail" title="E-mail the corresponding author ; Raquel Almansaa ; b ; ralmansa@saludcastillayleon.es" class="auth_mail" title="E-mail the corresponding author ; Francisco Gandí ; ab ; c ; fgandia@saludcastillayleon.es" class="auth_mail" title="E-mail the corresponding author ; Jose Ignacio Gó ; mez-Herrerasb ; d ; jgomez012001@yahoo.es" class="auth_mail" title="E-mail the corresponding author ; Esther Gomez-Sanchezb ; d ; esthergzam@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Heredia-Rodrí ; guezb ; d ; maria_her_05@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jose Maria Eirosb ; eiros@med.uva.es" class="auth_mail" title="E-mail the corresponding author ; David J. Kelvine ; f ; g ; h ; dkelvin@jidc.org" class="auth_mail" title="E-mail the corresponding author ; Eduardo Tamayob ; d ; h ; eduardo.tamayo@uva.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunological ; Dysfunction ; Sepsis ; Antigen presentation ; T/B lymphocytes ; Tregs ; PD-1 ; Immunoglobulins ; Neutrophils ; Complement
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：72
- 期：5
- 页码：525-536
- 全文大小：911 K
文摘
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Immuno-suppression/dysregulation is a major event in sepsis.
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Precision therapies with immuno-modulators could have a prominent role in sepsis.
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Defining major immunological alterations will be thus key for sepsis treatment.
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We have defined ten immunological features in sepsis.
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Assessing them could help to predict evolution and to individualise treatment.