Comparative tissue distribution and excretion study of alkaloids from Herba Ephedrae-Radix Aconiti Lateralis extracts in rats

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• 作者：Mengyue Ren^a ; ^b ; ¹ ; Shuai Song^c ; ^d ; ¹ ; Dedong Liang^a ; ^b ; Weiting Hou^a ; ^b ; Xiaomei Tan^a ; ^b ; ^{tanxm_smu@163.com} ; Jiabo Luo^a ; ^b ; ^{ljb@smu.edu.cn}
• 关键词：Mahuang-Fuzi ; Alkaloids ; UPLC-MS-MS ; Distribution ; Excretion
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：137-142
• 全文大小：888 K
• 卷排序：134

文摘

Aconitine alkaloids were excreted mainly through feces. Fecal excretion of aconitine alkaloids might be related to high expression of MRAP 2. The combination of Mahuang and Fuzi may increases the risk of drug accumulation.