Diketopiperazine indole alkaloids from hemp seed

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• 作者：Xiaoli Yan ; Yuefang Zhou ; Jiajing Tang ; Mei Ji ; Hongxiang Lou ; Peihong Fan ; ^{fanpeihong@sdu.edu.cn}
• 关键词：Hemp seed ; Diketopiperazine indole alkaloids ; Dihydroxyisoechinulin ; Neoechinulin A ; Stereoisomers
• 刊名：Phytochemistry Letters
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：Complete
• 页码：77-82
• 全文大小：1047 K
• 卷排序：18

文摘

Diketopiperazine indole alkaloids were isolated from hemp seed for the first time. Structures were elucidated with multiple spectra and chiral HPLC analysis techniques. The isolated compounds were constituents of hemp seed rather than that of fungal contamination. This work support the literature prediction of indole alkaloids in hemp seed. Neoechinulin A could promote SIRT1 expression in HEK293 cell lines.