Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson’s disease
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- 作者：Zhimin Wang&dagger ; ; Jiajia Wu&dagger ; ; Xuelian Yang ; Pei Cai ; Qiaohong Liu ; Kelvin D.G. Wang ; Lingyi Kong ; cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaobing Wang ; xbwang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson&rsquo ; s disease ; Monoamine oxidase ; BBB permeability ; Apoptosis ; Neuroprotection
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：24
- 期：22
- 页码：5929-5940
- 全文大小：3183 K
文摘
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A series of representative benzyloxy substituted MAO-B inhibitors were synthesized and evaluated.
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Compounds 5–8, 12–17, 25, 28 and 31 exhibited neuroprotective effects against 6-OHDA- and rotenone-treated PC12 cells.
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Compound 13 showed neuroprotective effects against neurotoxins-induced ROS accumulation and apoptosis.
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Compound 13 might be promising candidates for the therapy of Parkinson’s disease.