Flavonoids from Caragana pruinosa roots

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• 作者：Wei Peng^a ; ^b ; ¹ ; Liang Wang^a ; ¹ ; Xu-Hui Qiu^a ; Yi-Ping Jiang^a ; Lan Pan^c ; Xiao-Guang Jia^c ; Lu-Ping Qin^a ; ^{qinsmmu@126.com" class="auth_mail" title="E-mail the corresponding author} ; Cheng-Jian Zheng^a ; ^{zhengchengjian1984@126.com" class="auth_mail" title="E-mail the corresponding author} ; ^{zheng_chengjian@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Caragana pruinosa ; Flavonoids ; Pruinosanones ; Nitric oxide
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：105-109
• 全文大小：386 K

文摘

A new pterocarpan derivative, pruinosanone D (1), a new isoflavonoid, pruinosanone E (2), and a new chalcone, pruinosanone F (3), were isolated from Caragana pruinosa roots, along with four known analogues (4–7), identified as 2,4-dihydroxy-3′-methoxy-4′-ethoxychalcone, 7,4-dihydroxyflavanone, butin and scutellaprostin C, respectively. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolated compounds to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages was also studied. Compound 1 were among the most potent NO production inhibitor, with IC₅₀ value of 0.62 μM.